10 free, exam-style Specialist in Blood Banking (SBB) practice questions with answers and explanations. No signup required. Work through them below, then take the full free SBB practice test to study every exam domain.
These 10 free SBB questions are organized by exam domain, so you can see how each part of the Specialist in Blood Banking blueprint is tested. Reveal the answer and explanation under each question.
A patient is scheduled to receive a directed red cell donation from his brother, placing him at increased risk for transfusion-associated graft-versus-host disease (TA-GVHD). Which component modification is REQUIRED to prevent this complication?
Correct answer: D - Gamma or X-ray irradiation
A patient's red cells type as group A (anti-A 4+, anti-B negative). Reverse grouping shows weak reactivity with A1 reagent cells (2+) and strong reactivity with B cells (4+); the autocontrol is negative. What is the MOST likely explanation for this discrepancy?
Correct answer: D - The patient is group A2 with anti-A1
Molecular testing on a pregnant woman reveals a partial D phenotype. With respect to Rh immune globulin (RhIG), this patient:
Correct answer: A - Is a candidate for RhIG because she can form anti-D
A Kleihauer-Betke test on an Rh-negative woman who delivered an Rh-positive infant reveals 1.4% fetal cells. Using an estimated maternal blood volume of 5,000 mL, how many vials of 300-mcg Rh immune globulin (RhIG) should be administered?
Correct answer: B - 3 vials
A child develops acute hemoglobinuria after a recent viral illness. The DAT is positive for complement (C3) only, and a biphasic hemolysin with anti-P specificity is demonstrated. The MOST likely diagnosis is:
Correct answer: B - Paroxysmal cold hemoglobinuria
During antibody identification, a patient's serum reacts with multiple panel cells at the antiglobulin (AHG) phase. When the panel is repeated using ficin-treated reagent cells, all reactivity disappears. Which antibody is MOST consistent with these results?
Correct answer: C - Anti-Fya
A patient with warm autoimmune hemolytic anemia has a panreactive antibody that masks any underlying alloantibodies. The patient was transfused 2 units of red cells 10 days ago. Which technique is MOST appropriate to detect clinically significant alloantibodies?
Correct answer: C - Differential adsorption using R1R1, R2R2, and rr cells
A patient develops acute dyspnea and bilateral pulmonary infiltrates 3 hours into a red cell transfusion. Which finding would BEST support a diagnosis of transfusion-associated circulatory overload (TACO) rather than transfusion-related acute lung injury (TRALI)?
Correct answer: C - An elevated BNP level
Eight days after receiving 2 units of red cells, a patient returns with fatigue, mild jaundice, and an unexplained fall in hemoglobin. The DAT is now positive (mixed-field), and anti-Jka, undetectable at the time of transfusion, is now identified. The MOST likely cause is:
Correct answer: A - Delayed hemolytic transfusion reaction
A transfusion recipient dies, and the death is determined to be related to the transfusion. In addition to notifying the FDA as soon as possible, the facility must submit a complete written report to the FDA's Center for Biologics Evaluation and Research (CBER) within:
Correct answer: B - 7 days
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